Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19).
Identifieur interne : 000834 ( Main/Exploration ); précédent : 000833; suivant : 000835Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19).
Auteurs : Damien Dupont [France] ; Jean Menotti [France] ; Jean Turc [France] ; Charline Miossec [France] ; Florent Wallet [France] ; Jean-Christophe Richard [France] ; Laurent Argaud [France] ; Sylvie Paulus [France] ; Martine Wallon [France] ; Florence Ader [France] ; Florence Persat [France]Source :
- Medical mycology [ 1460-2709 ] ; 2020.
Abstract
Occurrence of putative invasive pulmonary aspergillosis was screened in 153 consecutive adult intensive care unit (ICU) patients with respiratory samples addressed for mycological diagnosis during a 6-week period at the emergence of coronavirus disease 2019 (COVID-19) pandemic. Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) was observed for 106 patients (69.3%). Nineteen of them (17.9%) with positive Aspergillus results were considered as having putative invasive pulmonary aspergillosis. These observations underline the risk of pulmonary aspergillosis in COVID-19 patients, even in patients not previously known to be immunosuppressed, advocating active search for Aspergillus infection and prompt antifungal treatment. Standardized surveillance protocols and updated definitions for ICU putative invasive pulmonary aspergillosis are needed.
LAY ABSTRACT
Adult ICU patients with respiratory samples addressed for mycological diagnosis were screened during the emergence of COVID-19 pandemic. Positive SARS-CoV-2 PCR was observed for 106 patients, nineteen of them (17.9%) having aspergillosis. This underlines the risk of aspergillosis in COVID-19 patients.
DOI: 10.1093/mmy/myaa078
PubMed: 32914189
PubMed Central: PMC7499748
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19).</title><author><name sortKey="Dupont, Damien" sort="Dupont, Damien" uniqKey="Dupont D" first="Damien" last="Dupont">Damien Dupont</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Menotti, Jean" sort="Menotti, Jean" uniqKey="Menotti J" first="Jean" last="Menotti">Jean Menotti</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Turc, Jean" sort="Turc, Jean" uniqKey="Turc J" first="Jean" last="Turc">Jean Turc</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Chirurgicale et Anesthésiologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Chirurgicale et Anesthésiologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Miossec, Charline" sort="Miossec, Charline" uniqKey="Miossec C" first="Charline" last="Miossec">Charline Miossec</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Wallet, Florent" sort="Wallet, Florent" uniqKey="Wallet F" first="Florent" last="Wallet">Florent Wallet</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Médicale, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, F-69495, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, F-69495</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Lyon, F-69007, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Lyon, F-69007</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Richard, Jean Christophe" sort="Richard, Jean Christophe" uniqKey="Richard J" first="Jean-Christophe" last="Richard">Jean-Christophe Richard</name><affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation et Surveillance Continue Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Intensive Réanimation et Surveillance Continue Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Argaud, Laurent" sort="Argaud, Laurent" uniqKey="Argaud L" first="Laurent" last="Argaud">Laurent Argaud</name><affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Paulus, Sylvie" sort="Paulus, Sylvie" uniqKey="Paulus S" first="Sylvie" last="Paulus">Sylvie Paulus</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Anesthésie-Réanimation du Pôle Est, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, F-69500, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie-Réanimation du Pôle Est, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, F-69500</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Wallon, Martine" sort="Wallon, Martine" uniqKey="Wallon M" first="Martine" last="Wallon">Martine Wallon</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Ader, Florence" sort="Ader, Florence" uniqKey="Ader F" first="Florence" last="Ader">Florence Ader</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Persat, Florence" sort="Persat, Florence" uniqKey="Persat F" first="Florence" last="Persat">Florence Persat</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32914189</idno><idno type="pmid">32914189</idno><idno type="doi">10.1093/mmy/myaa078</idno><idno type="pmc">PMC7499748</idno><idno type="wicri:Area/Main/Corpus">000163</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000163</idno><idno type="wicri:Area/Main/Curation">000163</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000163</idno><idno type="wicri:Area/Main/Exploration">000163</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19).</title><author><name sortKey="Dupont, Damien" sort="Dupont, Damien" uniqKey="Dupont D" first="Damien" last="Dupont">Damien Dupont</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Menotti, Jean" sort="Menotti, Jean" uniqKey="Menotti J" first="Jean" last="Menotti">Jean Menotti</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Turc, Jean" sort="Turc, Jean" uniqKey="Turc J" first="Jean" last="Turc">Jean Turc</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Chirurgicale et Anesthésiologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Chirurgicale et Anesthésiologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Miossec, Charline" sort="Miossec, Charline" uniqKey="Miossec C" first="Charline" last="Miossec">Charline Miossec</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Wallet, Florent" sort="Wallet, Florent" uniqKey="Wallet F" first="Florent" last="Wallet">Florent Wallet</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Médicale, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, F-69495, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, F-69495</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Lyon, F-69007, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Lyon, F-69007</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Richard, Jean Christophe" sort="Richard, Jean Christophe" uniqKey="Richard J" first="Jean-Christophe" last="Richard">Jean-Christophe Richard</name><affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation et Surveillance Continue Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Intensive Réanimation et Surveillance Continue Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Argaud, Laurent" sort="Argaud, Laurent" uniqKey="Argaud L" first="Laurent" last="Argaud">Laurent Argaud</name><affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Paulus, Sylvie" sort="Paulus, Sylvie" uniqKey="Paulus S" first="Sylvie" last="Paulus">Sylvie Paulus</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Anesthésie-Réanimation du Pôle Est, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, F-69500, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie-Réanimation du Pôle Est, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, F-69500</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Wallon, Martine" sort="Wallon, Martine" uniqKey="Wallon M" first="Martine" last="Wallon">Martine Wallon</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Ader, Florence" sort="Ader, Florence" uniqKey="Ader F" first="Florence" last="Ader">Florence Ader</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Persat, Florence" sort="Persat, Florence" uniqKey="Persat F" first="Florence" last="Persat">Florence Persat</name><affiliation wicri:level="3"><nlm:affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author></analytic><series><title level="j">Medical mycology</title><idno type="eISSN">1460-2709</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Occurrence of putative invasive pulmonary aspergillosis was screened in 153 consecutive adult intensive care unit (ICU) patients with respiratory samples addressed for mycological diagnosis during a 6-week period at the emergence of coronavirus disease 2019 (COVID-19) pandemic. Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) was observed for 106 patients (69.3%). Nineteen of them (17.9%) with positive Aspergillus results were considered as having putative invasive pulmonary aspergillosis. These observations underline the risk of pulmonary aspergillosis in COVID-19 patients, even in patients not previously known to be immunosuppressed, advocating active search for Aspergillus infection and prompt antifungal treatment. Standardized surveillance protocols and updated definitions for ICU putative invasive pulmonary aspergillosis are needed.</div><div type="abstract" xml:lang="en"><p><b>LAY ABSTRACT</b></p><p>Adult ICU patients with respiratory samples addressed for mycological diagnosis were screened during the emergence of COVID-19 pandemic. Positive SARS-CoV-2 PCR was observed for 106 patients, nineteen of them (17.9%) having aspergillosis. This underlines the risk of aspergillosis in COVID-19 patients.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32914189</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2709</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Sep</Month><Day>10</Day></PubDate></JournalIssue><Title>Medical mycology</Title><ISOAbbreviation>Med. Mycol.</ISOAbbreviation></Journal><ArticleTitle>Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19).</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">myaa078</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/mmy/myaa078</ELocationID><Abstract><AbstractText>Occurrence of putative invasive pulmonary aspergillosis was screened in 153 consecutive adult intensive care unit (ICU) patients with respiratory samples addressed for mycological diagnosis during a 6-week period at the emergence of coronavirus disease 2019 (COVID-19) pandemic. Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) was observed for 106 patients (69.3%). Nineteen of them (17.9%) with positive Aspergillus results were considered as having putative invasive pulmonary aspergillosis. These observations underline the risk of pulmonary aspergillosis in COVID-19 patients, even in patients not previously known to be immunosuppressed, advocating active search for Aspergillus infection and prompt antifungal treatment. Standardized surveillance protocols and updated definitions for ICU putative invasive pulmonary aspergillosis are needed.</AbstractText><AbstractText Label="LAY ABSTRACT" NlmCategory="UNASSIGNED">Adult ICU patients with respiratory samples addressed for mycological diagnosis were screened during the emergence of COVID-19 pandemic. Positive SARS-CoV-2 PCR was observed for 106 patients, nineteen of them (17.9%) having aspergillosis. This underlines the risk of aspergillosis in COVID-19 patients.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dupont</LastName><ForeName>Damien</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Menotti</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turc</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service de Réanimation Chirurgicale et Anesthésiologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miossec</LastName><ForeName>Charline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallet</LastName><ForeName>Florent</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Service de Réanimation Médicale, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, F-69495, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Lyon, F-69007, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richard</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation et Surveillance Continue Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Argaud</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, F-69437, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paulus</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service d'Anesthésie-Réanimation du Pôle Est, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, F-69500, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallon</LastName><ForeName>Martine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Physiologie intégrée du système d'éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, F-69500, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ader</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Persat</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institut des Agents Infectieux, Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, F-69004, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>EA7426 PI3 - Inflammation and Immunity of the Respiratory Epithelium, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69495, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Med Mycol</MedlineTA><NlmUniqueID>9815835</NlmUniqueID><ISSNLinking>1369-3786</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aspergillus
</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">COVID-19 associated pulmonary aspergillosis (CAPA)</Keyword><Keyword MajorTopicYN="N">acute respiratory distress syndrome</Keyword><Keyword MajorTopicYN="N">intensive care unit</Keyword><Keyword MajorTopicYN="N">pulmonary aspergillosis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>08</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>11</Day><Hour>5</Hour><Minute>46</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32914189</ArticleId><ArticleId IdType="pii">5903915</ArticleId><ArticleId IdType="doi">10.1093/mmy/myaa078</ArticleId><ArticleId IdType="pmc">PMC7499748</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2012 Jul 1;186(1):56-64</Citation><ArticleIdList><ArticleId IdType="pubmed">22517788</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 Jun;8(6):e48-e49</Citation><ArticleIdList><ArticleId IdType="pubmed">32445626</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2020 Jul 1;202(1):132-135</Citation><ArticleIdList><ArticleId IdType="pubmed">32396381</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Mycol. 2006 Sep 1;44(Supplement_1):S71-S76</Citation><ArticleIdList><ArticleId IdType="pubmed">30408937</ArticleId></ArticleIdList></Reference><Reference><Citation>Mycoses. 2020 Jun;63(6):528-534</Citation><ArticleIdList><ArticleId IdType="pubmed">32339350</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2012 Feb 23;119(8):1831-7; quiz 1956</Citation><ArticleIdList><ArticleId IdType="pubmed">22010103</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Sep 12;71(6):1367-1376</Citation><ArticleIdList><ArticleId IdType="pubmed">31802125</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2012 Jun 20;307(23):2526-33</Citation><ArticleIdList><ArticleId IdType="pubmed">22797452</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2018 Oct;6(10):782-792</Citation><ArticleIdList><ArticleId IdType="pubmed">30076119</ArticleId></ArticleIdList></Reference><Reference><Citation>Mycoses. 2019 Apr;62(4):310-319</Citation><ArticleIdList><ArticleId IdType="pubmed">30426598</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mycol Med. 2020 Jun;30(2):100971</Citation><ArticleIdList><ArticleId IdType="pubmed">32307254</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 May;8(5):475-481</Citation><ArticleIdList><ArticleId IdType="pubmed">32105632</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Infect Dis. 2018 Dec;31(6):471-480</Citation><ArticleIdList><ArticleId IdType="pubmed">30299367</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Microbe. 2020 Jun;1(2):e53-e55</Citation><ArticleIdList><ArticleId IdType="pubmed">32835328</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Microbiol. 2017 Jul;55(7):2153-2161</Citation><ArticleIdList><ArticleId IdType="pubmed">28446576</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><orgName><li>Université Claude Bernard Lyon 1</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dupont, Damien" sort="Dupont, Damien" uniqKey="Dupont D" first="Damien" last="Dupont">Damien Dupont</name></region><name sortKey="Ader, Florence" sort="Ader, Florence" uniqKey="Ader F" first="Florence" last="Ader">Florence Ader</name><name sortKey="Argaud, Laurent" sort="Argaud, Laurent" uniqKey="Argaud L" first="Laurent" last="Argaud">Laurent Argaud</name><name sortKey="Dupont, Damien" sort="Dupont, Damien" uniqKey="Dupont D" first="Damien" last="Dupont">Damien Dupont</name><name sortKey="Menotti, Jean" sort="Menotti, Jean" uniqKey="Menotti J" first="Jean" last="Menotti">Jean Menotti</name><name sortKey="Menotti, Jean" sort="Menotti, Jean" uniqKey="Menotti J" first="Jean" last="Menotti">Jean Menotti</name><name sortKey="Miossec, Charline" sort="Miossec, Charline" uniqKey="Miossec C" first="Charline" last="Miossec">Charline Miossec</name><name sortKey="Paulus, Sylvie" sort="Paulus, Sylvie" uniqKey="Paulus S" first="Sylvie" last="Paulus">Sylvie Paulus</name><name sortKey="Persat, Florence" sort="Persat, Florence" uniqKey="Persat F" first="Florence" last="Persat">Florence Persat</name><name sortKey="Persat, Florence" sort="Persat, Florence" uniqKey="Persat F" first="Florence" last="Persat">Florence Persat</name><name sortKey="Richard, Jean Christophe" sort="Richard, Jean Christophe" uniqKey="Richard J" first="Jean-Christophe" last="Richard">Jean-Christophe Richard</name><name sortKey="Turc, Jean" sort="Turc, Jean" uniqKey="Turc J" first="Jean" last="Turc">Jean Turc</name><name sortKey="Wallet, Florent" sort="Wallet, Florent" uniqKey="Wallet F" first="Florent" last="Wallet">Florent Wallet</name><name sortKey="Wallet, Florent" sort="Wallet, Florent" uniqKey="Wallet F" first="Florent" last="Wallet">Florent Wallet</name><name sortKey="Wallon, Martine" sort="Wallon, Martine" uniqKey="Wallon M" first="Martine" last="Wallon">Martine Wallon</name><name sortKey="Wallon, Martine" sort="Wallon, Martine" uniqKey="Wallon M" first="Martine" last="Wallon">Martine Wallon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000834 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000834 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32914189
|texte= Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19).
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32914189" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
| This area was generated with Dilib version V0.6.37. |  |